Phantoms mimicking the viscoelastic behavior of healthy and fibrotic livers with Magnetic Resonance Elastography technique - Archive ouverte HAL Access content directly
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Phantoms mimicking the viscoelastic behavior of healthy and fibrotic livers with Magnetic Resonance Elastography technique

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Mashhour Chakouch
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  • PersonId : 1125589
Fabrice Charleux
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  • PersonId : 1125590
Sabine Bensamoun

Abstract

The purpose was to develop phantoms mimicking the viscoelastic properties of healthy and fibrotic livers. Three plastic phantoms composed of different concentrations (from 40% to 60%) were characterized at 60 Hz using Magnetic Resonance Elastography (MRE) tests. In parallel, the functional behavior (elasticity and viscosity) of healthy (N = 10) and fibrotic (minor: N = 20 and major: N = 10) livers were determined with MRE. The same MRE protocol (driver, frequency, MR sequence) was used for in vivo and in vitro experiments. MRE post-processing was realized with two methods allowing for the local measurement of the mechanical properties (shear modulus: µ) and the global analysis of the viscoelastic behavior through cartographies of storage (G') and loss (G'') modulus. The results showed an increase of the viscoelastic (G', G'') values as a function of the plastic concentration and as a function of the fibrosis level. The phantoms made of 40 %, 50 % and 60 % showed similar elastic properties of healthy (F0), minor (F1-F2) and major (F3-F4) liver fibrosis, respectively. This study has demonstrated that the developed phantoms could mimic the functional properties of healthy and fibrotic livers.
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Dates and versions

hal-03797330 , version 1 (04-10-2022)

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Mashhour Chakouch, Gwladys Leclerc, Fabrice Charleux, Sabine Bensamoun. Phantoms mimicking the viscoelastic behavior of healthy and fibrotic livers with Magnetic Resonance Elastography technique. IEEE-ICABME 3rd International Conference on Advances In Biomedical Engineering, Sep 2015, Beyrouth, Lebanon. ⟨10.1109/ICABME.2015.7323301⟩. ⟨hal-03797330⟩
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