Highly Effective Synthesis of C-5-Substituted 2′-Deoxyuridine Using Suzuki-Miyaura Cross-Coupling in Water - Université de technologie de Compiègne Access content directly
Journal Articles Synthesis: Journal of Synthetic Organic Chemistry Year : 2012

Highly Effective Synthesis of C-5-Substituted 2′-Deoxyuridine Using Suzuki-Miyaura Cross-Coupling in Water

Abstract

An efficient protocol to provide a series of C-5-substituted 2′-deoxyuridine derivatives using a palladium-catalyzed Suzuki-Miyaura cross-coupling reaction in water has been established. Starting from 2′-deoxyuridine derivatives, the target nucleoside analogues were obtained in good yields with low levels of palladium loading without protection of any hydroxyl group of the glycone moiety.
No file

Dates and versions

hal-04391387 , version 1 (12-01-2024)

Identifiers

Cite

Guillaume Sartori, Gérald Enderlin, Gwénaelle Hervé, Christophe Len. Highly Effective Synthesis of C-5-Substituted 2′-Deoxyuridine Using Suzuki-Miyaura Cross-Coupling in Water. Synthesis: Journal of Synthetic Organic Chemistry, 2012, 44 (05), pp.767-772. ⟨10.1055/s-0031-1289709⟩. ⟨hal-04391387⟩
4 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More