Improved microwave-assisted ligand-free Suzuki–Miyaura cross-coupling of 5-iodo-2′-deoxyuridine in pure water - Université de technologie de Compiègne Access content directly
Journal Articles New Journal of Chemistry Year : 2013

Improved microwave-assisted ligand-free Suzuki–Miyaura cross-coupling of 5-iodo-2′-deoxyuridine in pure water

Abstract

A facile and efficient methodology for direct synthesis of 5-aryl-2′-deoxyuridines was developed through ligand-free Suzuki–Miyaura cross-coupling reactions starting from totally deprotected 5-iodo-2′-deoxyuridine and various boronic acids. Reactions were performed, in pure water, in the presence of very low loading of palladium either by classical thermal heating or with the assistance of microwave irradiation yielding 5-arylated uridine derivatives in moderate to good yields within short reaction times.
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Dates and versions

hal-04391366 , version 1 (12-01-2024)

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Shawn Gallagher-Duval, Gwénaëlle Hervé, Guillaume Sartori, Gérald Enderlin, Christophe Len. Improved microwave-assisted ligand-free Suzuki–Miyaura cross-coupling of 5-iodo-2′-deoxyuridine in pure water. New Journal of Chemistry, 2013, 37 (7), pp.1989. ⟨10.1039/c3nj00174a⟩. ⟨hal-04391366⟩
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