Palladium-catalyzed Suzuki reaction in aqueous solvents applied to unprotected nucleosides and nucleotides - Université de technologie de Compiègne Access content directly
Journal Articles RSC Advances Year : 2014

Palladium-catalyzed Suzuki reaction in aqueous solvents applied to unprotected nucleosides and nucleotides

Abstract

Nucleoside analogues have attracted much attention due to their potential biological activities. Amongst all synthetic nucleosides, C5-modified pyrimidines and C2- or C8-modified purines have been particularly studied. A large variety of palladium cross-coupling reactions, with a majority of them based on the Suzuki–Miyaura reaction, have been developed for preparing the desired nucleoside derivatives. Our objective is to focus this review on the Suzuki–Miyaura cross-coupling of nucleosides using methodologies compatible with green chemistry and sustainable development for one part and bioorthogonality for the other part, which means using aqueous medium and no protection/deprotection steps.
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hal-04391336 , version 1 (12-01-2024)

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Gwénaëlle Hervé, Guillaume Sartori, Gérald Enderlin, Grahame Mackenzie, Christophe Len. Palladium-catalyzed Suzuki reaction in aqueous solvents applied to unprotected nucleosides and nucleotides. RSC Advances, 2014, 4 (36), pp.18558-18594. ⟨10.1039/c3ra47911k⟩. ⟨hal-04391336⟩
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