Abstract Operational Excellence (EO) is increasingly present in scientific and managerial news. Increasing competition, increasingly uncertain events, demands customers and society increasingly pressing, the evolution of systems towards cyber physics systems, push organizations to adapt their engineering methodologies. Excellence operational (EO) is one of the answers proposed by the scientific literature to make engineering organizations more flexible, more responsive, more efficient and therefore more competitive. In this article, we share a state of the art of operational excellence (EO) in system engineering (IS) through its most modern methodologies: the Lean Six Sigma (LSS), Theory of Constraints (TOC) and Agility (A) with an operational approach including social and societal responsibility via the Quality-Cost-Delay-Security-Environment (QCDSE). We finish by sharing four assumptions that will serve as a basis, in our future contribution, to propose a synergy solution to implement an Operational Excellence approach in systems engineering organizations.