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Mechanical properties of native and decellularized porcine oesophagus wall

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Romane Lesieur
  • Function : Author
  • PersonId : 1111706
Marlène Durand

Abstract

Esophageal tissue engineering is a promising approach to create an esophageal substitute and improve clinical results in esophageal surgery. The CIC's group has optimized a dynamic chemical and enzymatic decellularization protocol of porcine esophagus. The obtained decellularized matrices (DM) are then mechanically and biologically characterized in order to evaluate their suitability to be recellularized and their future clinical relevance. Three types of mechanical tests are performed: suturability (determination of the traction force that induces the suture rupture), longitudinal and circumferential capacity of extension, and burst tests (determination of the internal pressure that induces rupture of the tissue). These experiments are performed by Romane Lesieur in Biotis Lab. Some relations tension-deformation may then be deduced. Results obtained with DMs are compared with those obtained with native esophageus.
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Dates and versions

hal-03948987 , version 1 (20-01-2023)

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  • HAL Id : hal-03948987 , version 1

Cite

Romane Lesieur, Marlène Durand, Agnès Drochon. Mechanical properties of native and decellularized porcine oesophagus wall. 1ères Journées du GDR MécaBio-Santé, Nov 2022, Paris, France. ⟨hal-03948987⟩
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