X-ray Microtomography to Assess Determinants of In Vivo N-Butyl Cyanoacrylate Glubran®2 Polymerization: A Rabbit-Model Study - Archive ouverte HAL Access content directly
Journal Articles Biomedicines Year : 2022

X-ray Microtomography to Assess Determinants of In Vivo N-Butyl Cyanoacrylate Glubran®2 Polymerization: A Rabbit-Model Study

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1
Kévin Guillen
Pierre-Olivier Comby
Anne-Virginie Salsac
Nicolas Falvo
  • Function : Author
Marc Lenfant
  • Function : Author
Alexandra Oudot
Hugo Sikner
  • Function : Author
Anne Dencausse
Emilie Laveissiere
  • Function : Author
Serge Ludwig
  • Function : Author
  • PersonId : 893244
Romaric Loffroy

Abstract

Although introduced decades ago, few cyanoacrylate glues have been approved for endovascular use, despite evidence of their usefulness, notably for complex procedures suchas hemostatic embolization. Indications include massive bleeding requiring emergent hemostasis and prevention of severe bleeding during scheduled surgery to remove a hypervascular tumor. Adding radiopaque Lipiodol Ultra Fluid® (LUF) modulates glue polymerization and allows fluoroscopic guidance, but few comparative in vivo studies have assessed the impact of the resulting change in glue concentration or of other factors such as target-vessel blood flow. In a rabbit model, we used ex vivo X-ray microtomography to assess the results of in vivo renal-artery embolization by various mixtures of N-butyl cyanoacrylate (NBCA), metacryloxysulfolane, and LUF. Overall, penetration to the superficial interlobular arteries was achieved in about two-thirds of cases and into the capillaries in nearly half the cases, while cast fragmentation was seen in slightly more than half the cases. Greater NBCA dilution and the blocked-blood-flow technique were independently associated with greater distality of penetration. Blocked-blood-flow injection was independently associated with absence of fragmentation, capillary penetration, a shorter cast-to-capsule distance, and higher cast attenuation. A larger mixture volume was independently associated with higher indexed cast ratio and deeper penetration. Finally, microtomography is an adapted tool to assess ex vivo distribution of glue cast.
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Dates and versions

hal-03877327 , version 1 (29-11-2022)

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Kévin Guillen, Pierre-Olivier Comby, Anne-Virginie Salsac, Nicolas Falvo, Marc Lenfant, et al.. X-ray Microtomography to Assess Determinants of In Vivo N-Butyl Cyanoacrylate Glubran®2 Polymerization: A Rabbit-Model Study. Biomedicines, 2022, 10 (10), pp.2625. ⟨10.3390/biomedicines10102625⟩. ⟨hal-03877327⟩
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