Loss of KLF10 expression does not affect the passive properties of single myofibrils
Abstract
The purpose of this study was to gain insight into the origin of the passive behavior observed in KLF10 KO soleus and EDL muscles, at the fiber scale and at the myofibril (titin) scale. The conclusion from the results of this study is that the observed fibre-type specific changes in passive force in KLF10 KO mice muscles are not caused by sarcomere intrinsic structures but must originate outside the sarcomeres, likely in the collagen-based extracellular matrix.
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