A new flow chamber for the study of shear stress and transmural pressure upon cells adhering to a porous biomaterial - Université de technologie de Compiègne Access content directly
Journal Articles Journal of Biomechanical Engineering Year : 2002

A new flow chamber for the study of shear stress and transmural pressure upon cells adhering to a porous biomaterial

Abstract

Biomaterials used in some biomedical devices are porous and exposed to normal and tangential flow of biofluids. To examine the influence of flow induced forces on the morphology and the biochemical responses of cells adhering to such biomaterials, a Hele-Shaw cell with a porous bottom wall was designed and characterized experimentally. Theoretical predictions for the flow in the chamber are provided and allow to quantify the shear stress and/or transmural pressure exerted on cells. It is thus possible to follow up continuously the shape changes of cells that are adherent on a permeable membrane used in bioreactors.
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Dates and versions

hal-02064220 , version 1 (11-03-2019)

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Roxana Chotard-Ghodsnia, Agnès Drochon, Reinhard Grebe. A new flow chamber for the study of shear stress and transmural pressure upon cells adhering to a porous biomaterial. Journal of Biomechanical Engineering, 2002, 124 (2), pp.258-261. ⟨10.1115/1.1448520⟩. ⟨hal-02064220⟩
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