Flax phenolic compounds as inhibitors of lipid oxidation: Elucidation of their mechanisms of action

Larissa Socrier 1 Anthony Quéro 2 Margaux Verdu Yiming Song Roland Molinié 3 David Mathiron 4 Serge Pilard 5 François Mesnard 6 Sandrine Morandat 1
1 GEC - Génie Enzymatique et Cellulaire
2 Biologie des plantes et innovation (BIOPI) EA3900
3 BIOPI - Biologie des Plantes et Innovation
4 LRCS - Laboratoire réactivité et chimie des solides
5 Plate-forme analytique
6 EA BIOPI Laboratoire de Phytotechnologie
Abstract : Polyunsaturated fatty acids are particularly sensitive to the damages due to reactive oxygen species and lipid oxidation has been reported to be involved in the degradation of food as well as in the early stages of several diseases. Our objective was to study the mechanisms of action of flax (Linum usitatissimum) phenolic compounds to prevent membrane lipid oxidation. To do so, several biophysical techniques (oxidative stress, surface tension, fluorescence spectroscopy and HPLC) were used to investigate the ability of the compounds to prevent lipid oxidation and to interact with membranes. We evidenced a relationship between the structure and the anti-oxidant efficiency as aglycone compounds were significantly more efficient (p < 0.05) than glucoside compounds. In addition, our results revealed that aglycone lignans spontaneously penetrated the membrane contrary to aglycone hydroxycinnamic acids. To conclude, the comparison of the antioxidant efficiencies revealed that membrane inserted compounds better inhibited lipid oxidation than non-inserted compounds.
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https://hal.utc.fr/hal-01988885
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Submitted on : Wednesday, January 23, 2019 - 11:46:15 AM
Last modification on : Thursday, February 7, 2019 - 3:14:01 PM

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UNIV-COMPIEGNE | GEC | GEC-UTC | CNRS | INC-CNRS

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Larissa Socrier, Anthony Quéro, Margaux Verdu, Yiming Song, Roland Molinié, et al.. Flax phenolic compounds as inhibitors of lipid oxidation: Elucidation of their mechanisms of action. Food Chemistry, Elsevier, 2019, 274, pp.651-658. ⟨10.1016/j.foodchem.2018.08.126⟩. ⟨hal-01988885⟩

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