Evaluation of Fibrin-Based Interpenetrating Polymer Networks as Potential Biomaterials for Tissue Engineering - Université de technologie de Compiègne Access content directly
Journal Articles Nanomaterials Year : 2017

Evaluation of Fibrin-Based Interpenetrating Polymer Networks as Potential Biomaterials for Tissue Engineering

Abstract

Interpenetrating polymer networks (IPNs) have gained great attention for a number of biomedical applications due to their improved properties compared to individual components alone. In this study, we investigated the capacity of newly-developed naturally-derived IPNs as potential biomaterials for tissue engineering. These IPNs combine the biologic properties of a fibrous fibrin network polymerized at the nanoscale and the mechanical stability of polyethylene oxide (PEO). First, we assessed their cytotoxicity in vitro on L929 fibroblasts. We further evaluated their biocompatibility ex vivo with a chick embryo organotypic culture model. Subcutaneous implantations of the matrices were subsequently conducted on nude mice to investigate their biocompatibility in vivo. Our preliminary data highlighted that our biomaterials were non-cytotoxic (viability above 90%). The organotypic culture showed that the IPN matrices induced higher cell adhesion (across all the explanted organ tissues) and migration (skin, intestine) than the control groups, suggesting the advantages of using a biomimetic, yet mechanically-reinforced IPN-based matrix. We observed no major inflammatory response up to 12 weeks post implantation. All together, these data suggest that these fibrin-based IPNs are promising biomaterials for tissue engineering.
Fichier principal
Vignette du fichier
nanomaterials-07-00436-v2.pdf (3.92 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-01950354 , version 1 (20-01-2024)

Identifiers

Cite

Olfat Gsib, Jean-Luc Duval, Mathieu Goczkowski, Marie Deneufchatel, Odile Fichet, et al.. Evaluation of Fibrin-Based Interpenetrating Polymer Networks as Potential Biomaterials for Tissue Engineering. Nanomaterials, 2017, 12 (12), pp.436. ⟨10.3390/nano7120436⟩. ⟨hal-01950354⟩
70 View
5 Download

Altmetric

Share

Gmail Facebook X LinkedIn More